hepatic infarct-like necrosis
Friday 23 March 2012
Infarct-like Necrosis of the liver
The response of colorectal adenocarcinoma liver metastases to perioperative chemotherapy can be assessed histologically in partial hepatectomy specimens. Necrosis in this scenario may represent a lack of treatment effect or a therapeutic response to chemotherapy.
Use of Tumor regression grade (TRG) did not demonstrate a significant difference in disease-free and overall survival.
An infarct-like necrosis (ILN) represents a form of treatment effect and should be distinguished from UN.
A modified grading system that incorporates ILN may enhance the prognostic utility of TRG.
Infarct-like Necrosis: A Distinct Form of Necrosis Seen in Colorectal Carcinoma Liver Metastases Treated With Perioperative Chemotherapy. Chang HH, Leeper WR, Chan G, Quan D, Driman DK. Am J Surg Pathol. 2012 Apr;36(4):570-6. PMID: 22301494