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hepatic infarct-like necrosis

Friday 23 March 2012

Infarct-like Necrosis of the liver

The response of colorectal adenocarcinoma liver metastases to perioperative chemotherapy can be assessed histologically in partial hepatectomy specimens. Necrosis in this scenario may represent a lack of treatment effect or a therapeutic response to chemotherapy.

Use of Tumor regression grade (TRG) did not demonstrate a significant difference in disease-free and overall survival.

An infarct-like necrosis (ILN) represents a form of treatment effect and should be distinguished from UN.

A modified grading system that incorporates ILN may enhance the prognostic utility of TRG.

References

- Infarct-like Necrosis: A Distinct Form of Necrosis Seen in Colorectal Carcinoma Liver Metastases Treated With Perioperative Chemotherapy. Chang HH, Leeper WR, Chan G, Quan D, Driman DK. Am J Surg Pathol. 2012 Apr;36(4):570-6. PMID: 22301494