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superficial esophageal squamous cell carcinoma

Monday 2 July 2012

Endoscopic resection is a less invasive treatment than esophagectomy for superficial esophageal squamous cell carcinoma, but patients with lymph node metastasis need additional treatment after endoscopic resection.

No additional treatment is needed for endoscopic resection cases with superficial esophageal squamous cell carcinoma (#22627741#):
- (1) thinner than 1200 μm;
- (2) confined to the mucosa;
- (3) with submucosal invasion <250 μm;
- (4) with submucosal invasion ≥250 μm but with negative VEGF expression and well/moderately differentiated or basaloid histology;
- (5) with submucosal invasion ≥250 μm but with weak VEGF expression and well-differentiated histology.

These clinical and pathological criteria should enable more accurate selection of patients for these procedures. (#22627741#)

References

- Parameters predicting lymph node metastasis in patients with superficial esophageal squamous cell carcinoma. Xue L, Ren L, Zou S, Shan L, Liu X, Xie Y, Zhang Y, Lu J, Lin D, Dawsey SM, Wang G, Lu N. Mod Pathol. 2012 May 25. PMID: #22627741#