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mammary metaplastic carcinoma

Sunday 8 July 2012

Metaplastic carcinoma of the breast, metaplastic breast carcinoma

Metaplastic breast carcinoma is a rare and aggressive histologic type of breast cancer, preferentially displaying a triple-negative phenotype.

Digital cases

- JRC:5046 : Metaplastic carcinoma of the breast.
- JRC:5047 : Metaplastic carcinoma of the breast.
- JRC:5048 : Metaplastic carcinoma of the breast.

The diversity of histologic features of metaplastic breast carcinomas is reflected at the transcriptomic level, and an association between molecular subtypes and histology was observed.

Molecular biology

BRCA1-like genomic profiles are found only in a subset (31%) of metaplastic breast cancers, and are not associated with a specific molecular or histologic subtype.

See also

- mammary carcinomas

Open references

- Metaplastic breast carcinomas display genomic and transcriptomic heterogeneity. Weigelt B, Ng CK, Shen R, Popova T, Schizas M, Natrajan R, Mariani O, Stern MH, Norton L, Vincent-Salomon A, Reis-Filho JS. Mod Pathol. 2015 Mar;28(3):340-51. doi : 10.1038/modpathol.2014.142 PMID: 25412848 (Free)