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chondroid syringoma

Wednesday 25 July 2012

Malignant Cutaneous Mixed Tumor


Definition: Cutaneous mixed tumor (chondroid syringoma) is the cutaneous counterpart of pleomorphic adenoma of salivary glands, comprised of both epithelial and mesenchymal components. Malignant transformation is exceptionally rare, with only a few cases reported.

Mixed tumor/chondroid syringoma which is characterized by PLAG1 gene rearrangement.


- Chondroid syringoma / PLAG1

- Malignant mixed tumor arising in chondroid syringoma : perineural invasion, mitosis

Differential diagnosis

- salivary mixed tumors
- malignant chondroid syringoma

See also

- cutaneous apocrine tumors
- mixed tumors
- syringoma

Open references

- Myoepithelial neoplasms of soft tissue: an updated review of the clinicopathologic, immunophenotypic, and genetic features. Jo VY, Fletcher CD. Head Neck Pathol. 2015 Mar;9(1):32-8. doi : 10.1007/s12105-015-0618-0
PMID: 25804378 (Free)