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flat epithelial atypia

Tuesday 7 August 2012

Differential diagnosis

- Flat epithelial atypia (FEA) of the breast

  • Flat epithelial atypia (FEA) of the breast typically is a localized alteration involving only few, neighboring terminal ducto-lobular units.
  • However, occasionally there are cases with extensive FEA and morphologic evidence of direct transitions between FEA and classical low-grade ductal carcinoma in situ (lg-DCIS).
  • There is a direct transitions between FEA and lg-DCIS and FEA can be considered as a part of the low-grade pathway in the development of breast cancer.

Reference

- Transitions Between Flat Epithelial Atypia and Low-grade Ductal Carcinoma In Situ of the Breast. Aulmann S, Braun L, Mietzsch F, Longerich T, Penzel R, Schirmacher P, Sinn HP. Am J Surg Pathol. 2012 Aug;36(8):1247-52. PMID: #22790863#