Monday 27 August 2012
Liposarcoma rarely occurs in the mediastinum.
The mediastinum shows a preponderance of uncommon subtypes and unusual morphologic variants.
Correct classification has important implications, with most patients with well-differentiated/dedifferentiated liposarcoma having a protracted clinical course, in contrast to the more rapid disease progression seen in patients with myxoid and pleomorphic liposarcoma.
pleomorphic liposarcomas (CPM- or DDIT3-)
unclassifiable liposarcoma (CPM- and DDIT3-)
- myxoid well-differentiated liposarcoma
- dedifferentiated liposarcoma with "meningothelial"-like dedifferentiation
- differentiated myxoid liposarcoma mimicking well-differentiated liposarcoma (CPM-)
- pleomorphic liposarcoma with epithelioid and myxoid change.
Liposarcomas of the mediastinum and thorax: a clinicopathologic and molecular cytogenetic study of 24 cases, emphasizing unusual and diverse histologic features. Boland JM, Colby TV, Folpe AL. Am J Surg Pathol. 2012 Sep;36(9):1395-403. PMID: 22895273