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The Bethesda System for Reporting Thyroid Cytopathology

Wednesday 12 September 2012

Items

- NONDIAGNOSTIC or UNSATISFACTORY

  • Cyst fluid only
  • Virtually acellular specimen
  • Other (obscuring blood, clotting artifact, etc.)

- BENIGN

  • Benign follicular nodule (includes adenomatoid nodule, colloid nodule, etc.)
  • Lymphocytic (Hashimoto) thyroiditis
  • Granulomatous (subacute) thyroiditis
  • Other

- ATYPIA OF UNDETERMINED SIGNIFICANCE or FOLLICULAR LESION OF UNDETERMINED SIGNIFICANCE

- FOLLICULAR NEOPLASM or SUSPICIOUS FOR A FOLLICULAR NEOPLASM

  • specify if Hürthle cell (oncocytic) type

- SUSPICIOUS FOR MALIGNANCY

  • Suspicious for papillary carcinoma
  • Suspicious for medullary carcinoma
  • Suspicious for metastatic carcinoma
  • Suspicious for lymphoma
  • Other

- MALIGNANT

  • Papillary thyroid carcinoma
  • Poorly differentiated carcinoma
  • Medullary thyroid carcinoma
  • Undifferentiated (anaplastic) carcinoma
  • Squamous cell carcinoma
  • Carcinoma with mixed features (specify)
  • Metastatic carcinoma
  • Non-Hodgkin lymphoma
  • Other

Links

- The Papanicolaou Society : http://www.papsociety.org/atlas.html
- AJCP

References

- NCI Thyroid fine needle aspiration state of science Conference. Diagn Cytopathol 2008;6:388–448.

- Ali S.Z., Cibas E.S. The Bethesda System for reporting thyroid cytopathology: definitions, criteria and explanatory notes New-York: Springer (2010).

- Kocjan G., Cochand-Priollet B., de Agustin P.P., Bourgain C., Chandra A., Daneshbod Y. , et al. Diagnostic terminology for reporting thyroid fine needle aspiration cytology: European Federation of Cytology Societies thyroid working party symposium, Lisbon 2009 Cytopathology 2010 ; 21 : 86-92

- The Papanicolaou Society of Cytopathology Task Force on Standards of Practice: guidelines of the Papanicolaou Society of cytopathology for the examination of fine needle aspiration specimens from thyroid nodules. Modern Pathol 1996;9:710–5.

- Cooper D.S., Doherty G.M., Haugen B.R., Kloos R.T., Lee S.L., Mandel S.J. , et al. Management guidelines for patients with thyroid nodules and differentiated thyroid cancer Thyroid 2006 ; 16 : 109-142

- AACE/AME, Task Force on Thyroid Nodules American Association of Clinical Endocrinologists and Associazione Medici Endocrinologi medical guidelines for clinical practice for the diagnosis and management of thyroid nodules Endocr Pract 2006 ; 12 : 63-102

- Agarwal A., Kocjan G. FNAC thyroid reporting categories: value of using the British Thyroid Association (Thy 1 to Thy 5) thyroid FNAC reporting guidelines Cytopathology 2009 ; 20 : 133-134

- Delellis R.A., Williams E.D. Tumours of the thyroid and parathyroid Pathology and genetics of tumours of endocrine organs Lyon: IARC Press (2004). 50-133

- Ali S.Z. Thyroid cytopathology: Bethesda and beyond Acta Cytol 2011 ; 55 : 4-12

- Filie A.C., Asa S.L., Geisinger K.R., Logani S., Merino M., Nikiforov Y.E. , et al. Utilization of ancillary studies in thyroid fine needle aspirates: a synopsis of the National Cancer Institute thyroid fine needle aspiration state of the science conference Diagn Cytopathol 2008 ; 36 : 438-441