multilocular renal cyst
Monday 1 October 2012
Multilocular renal cyst is an uncommon lesion of uncertain pathogenesis seen in children and adults.
All cases have strong and uniform cytoplasmic staining of lining epithelial cells for keratin and binding sites for arachis hypogaea lectin, similar to that seen for the distal convoluted tubules or collecting ducts in normal kidney.
There is a variable expression of other distal nephron markers, including epithelial membrane antigen (EMA) and Ber-EP4.
Furthermore, lining cells in some lesions coexpress proximal nephron markers such as alpha-1-antitrypsin and lysozyme, as well as binding sites for lotus tetragonolobus lectin.
Immunostaining for type IV (basement membrane) collagen demonstrates a continuous subepithelial basement membrane zone and basal laminae surrounding desmin-positive stromal cells.
Areas of active collagen synthesis and stromal procollagen deposition are visualized within the interlocular septae using a monoclonal antibody to type I procollagen.
Significant proliferative activity is not detected in the lining epithelium or stroma using the anti-proliferating cell nuclear antigen.
MRCs show aberrant tubular epithelial glycoprotein and glycoconjugate expression, low proliferative activity, and associated activation of interlocular stromal cells.
renal simple cyst
Multilocular renal cyst. Immunohistochemical and lectin-binding study. Davila RM, Kissane JM, Crouch EC. Am J Surg Pathol. 1992 May;16(5):508-14. PMID: 1376021