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gastric epithelial dysplasia type 1

Tuesday 2 October 2012

gastric adenomatous dysplasia

The term "gastric adenomatous dysplasia" has been quoted to emphasise the similarity between the histological features of adenomatous lesions of the colon and dysplastic lesions arising in chronic inflammatory bowel disease and Barrett’s epithelium.

Some confusion exists in relation to the usage of the terms adenoma and dysplasia. "Gastric dysplasia" can arise as a flat or depressed process or present as a raised circumscribed lesion protruding above the mucosal surface, sometimes referred to as an adenoma. Most "gastric adenomas" are sessile and display either a flat (tubular), a tubulovillous or villous architecture.

The term "cryptal dysplasi"a has been used to describe the dysplastic changes involving predominantly the deeper portion of the mucosa.

Synopsis

- Low grade dysplasia, adenomatous type.

  • Large tubules resembling colonic adenomas.
  • At higher magnification, the cells have elongated, closely packed nuclei with dense chromatin.
  • Nuclei are confined to the basal half of the cells and retain their polarity.