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gastric epithelial dysplasia type 2

Tuesday 2 October 2012

gastric hyperplastic dysplasia

Type II dysplasia, reported by some as "hyperplastic dysplasia", also frequently arises on a background of chronic atrophic gastritis with immature intestinal metaplasia.

The histological features are less well established than in "adenomatous dysplasia".

Architecturally, it may display foveolar hyperplasia with irregular glandular branching and epithelial folding.

The lining epithelium is formed of tall columnar cells with pale cytoplasm with loss of polarity, hyperchromatic ovoid nuclei and few goblet cells.

The mild form of this type of dysplasia is easily confused with regenerative changes.

In the severe form, prominent vesicular nuclei with an increased nuclear: cytoplasmic ratio and prominent nucleoli are seen.

Nuclear stratification and numerous mitoses can also be seen.

Synopsis

- High grade type 2, hyperplastic dysplasia

  • Closely packed glands with mild luminal festooning.
  • At higher magnification, the cells display oval/round open nuclei with prominent nucleoli.
  • Frequent mitoses can be seen.
  • The nuclei reach the apical region of the cells and their polarity is partially lost.

See also

- gastric epithelial dysplasia