Home > A. Molecular pathology > ZEB1

ZEB1

HGNC:11642 MIM.189909

Monday 17 December 2012

zinc finger E-box binding homeobox 1; info "posterior polymorphous corneal dystrophy 3", PPCD3, TCF8, "transcription factor 8 (represses interleukin 2 expression)"

Definition: ZEB1 encodes a zinc finger transcription factor that represses T-lymphocyte-specific IL2 gene (MIM.147680) expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.

IHC

- nuclear expression of ZEB1 indicated an adverse outcome. (#23190132#)

  • ZEB1 seems to be the main one associated with adverse clinical presentation and clinical outcome. (#23190132#)
  • Further studies are needed to evaluate whether inhibition of ZEB1 could serve as a therapeutic target. (#23190132#)

Reference

- Biological roles and prognostic values of the epithelial-mesenchymal transition-mediating transcription factors Twist, ZEB1 and Slug in diffuse large B-cell lymphoma. Lemma S, Karihtala P, Haapasaari KM, Jantunen E, Soini Y, Bloigu R, Pasanen AK, Turpeenniemi-Hujanen T, Kuittinen O. Histopathology. 2012 Jul 26. PMID: #23190132#