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thyroid poorly differentiated oncocytic thyroid carcinoma

Thursday 20 December 2012

Poorly differentiated Hurthle cell carcinoma of the thyroid.

Digital cases

- JRC:329 : Poorly differentiated Hurthle cell carcinoma of the thyroid.

Poorly differentiated thyroid carcinomas (PDTC) are an ongoing diagnostic challenge.

Although the Turin consensus criteria for PDTC excluded consideration of oncocytic tumours, the World Health Organization (WHO) classification does recognise an oncocytic variant of conventional PDTC. The Turin criteria can be applied to oncocytic PDTC and patients with this variant have a decreased survival using conventional radioiodine treatment compared to conventional PDTC and might therefore be candidates for novel treatment modalities.

References

- Poorly differentiated oncocytic thyroid carcinoma—diagnostic implications and outcome. Dettmer M, Schmitt A, Steinert H, Moch H, Komminoth P, Perren A. Histopathology. 2012 Jun;60(7):1045-51. PMID: #22348590#