Thursday 20 December 2012
Definition: Discoidin domain receptor family, member 2, also known as DDR2 or CD167b (cluster of differentiation 167b), is a human gene coding for a receptor tyrosine kinases (RTK).
This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain.
Alternative splicing in the 5’ UTR results in multiple transcript variants encoding the same protein.
Mutations in the DDR2 kinase gene in pulmonary squamous cell carcinoma (#22328973#) [Free]
Acquired resistance to dasatinib in lung cancer cell lines conferred by DDR2 gatekeeper mutation and NF1 loss. (#24296828#)
Receptor tyrosine kinases (RTKs)
- Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment.
- These molecules are involved in the regulation of cell growth, differentiation, and metabolism.
- In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation.
- This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction.
- RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions.
Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Hammerman PS, Sos ML, Ramos AH et al. Cancer Discov. 2011 Jun;1(1):78-89. PMID: #22328973# [Free]