Friday 21 December 2012
The cancer-testis (CT) family of antigens is expressed in a variety of malignant neoplasms. MAGE-C2/CT-10 is a novel CT antigen.
CT antigens are promising targets for immunotherapy in cancer because their expression is restricted to cancer and germ line cells and a proportion of cancer patients presents with immune responses against CT antigens, which clearly demonstrates their immunogenicity.
MAGE-C2/CT10 protein expression is an independent predictor of recurrence in prostate cancer. von Boehmer L, Keller L, Mortezavi A, Provenzano M, Sais G, Hermanns T, Sulser T, Jungbluth AA, Old LJ, Kristiansen G, van den Broek M, Moch H, Knuth A, Wild PJ. PLoS One. 2011;6(7):e21366. PMID: 21754986 (Free)
Expression of MAGE-C1/CT7 and MAGE-C2/CT10 predicts lymph node metastasis in melanoma patients. Curioni-Fontecedro A, Nuber N, Mihic-Probst D, Seifert B, Soldini D, Dummer R, Knuth A, van den Broek M, Moch H. PLoS One. 2011;6(6):e21418. PMID: 21738656 [Free]