Home > A. Molecular pathology > MAGE-C1/CT7

MAGE-C1/CT7

Friday 21 December 2012

The cancer-testis (CT) family of antigens is expressed in a variety of malignant neoplasms. MAGE-C2/CT-10 is a novel CT antigen.

MAGE-C1/CT7 and MAGE-C2/CT10 are members of the large MAGE family of cancer-testis (CT) antigens.

CT antigens are promising targets for immunotherapy in cancer because their expression is restricted to cancer and germ line cells and a proportion of cancer patients presents with immune responses against CT antigens, which clearly demonstrates their immunogenicity.

Pathology

- MAGE-C2/CT10 could be a potential target for adjuvant and palliative immunotherapy in patients with prostate cancer. (21754986)

- The expression of MAGE-C1/CT7 and MAGE-C2/CT10 in primary melanoma is a potent predictor of sentinel lymph node metastasis. (21738656)

Open References

- MAGE-C2/CT10 protein expression is an independent predictor of recurrence in prostate cancer. von Boehmer L, Keller L, Mortezavi A, Provenzano M, Sais G, Hermanns T, Sulser T, Jungbluth AA, Old LJ, Kristiansen G, van den Broek M, Moch H, Knuth A, Wild PJ. PLoS One. 2011;6(7):e21366. PMID: 21754986 (Free)

- Expression of MAGE-C1/CT7 and MAGE-C2/CT10 predicts lymph node metastasis in melanoma patients. Curioni-Fontecedro A, Nuber N, Mihic-Probst D, Seifert B, Soldini D, Dummer R, Knuth A, van den Broek M, Moch H. PLoS One. 2011;6(6):e21418. PMID: 21738656 [Free]