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POSTN

HGNC:16953 13q13.3

Friday 21 December 2012

periostin; periostin, osteoblast specific factor; OSF-2, periostin, PN

WP

Definition: Periostin (POSTN, PN, or osteoblast-specific factor OSF-2) is a protein that in humans is encoded by the POSTN gene.

Periostin functions as a ligand for alpha-V/beta-3 and alpha-V/beta-5 integrins to support adhesion and migration of epithelial cells. Periostin is a gla domain vitamin K dependent factor.

Images

- In basal membrane of bronchial mucosa

Pathology

- periostin splice variants in renal cell carcinoma (21763681)

Reference

- Relevance of periostin splice variants in renal cell carcinoma. Morra L, Rechsteiner M, Casagrande S, Duc Luu V, Santimaria R, Diener PA, Sulser T, Kristiansen G, Schraml P, Moch H, Soltermann A. Am J Pathol. 2011 Sep;179(3):1513-21. PMID: 21763681 [Free]