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HOXC13

Sunday 30 December 2012

Pathology

- Increased HOX C13 expression in metastatic melanoma progression. (#22583695#)

  • Deregulated paralogous group 13 HOX genes expression has been detected in melanoma, cervical cancer and odonthogenic tumors.
  • Among these, Hox C13 is also involved in the expression control of the human keratin genes hHa5 and hHa2, and recently it was identified as a member of human DNA replication complexes.
  • Some results show the strong and progressive HOX C13 overexpression in metastatic melanoma tissues and cytological samples compared to nevi and primary melanoma tissues and cells.
  • It suggests a possible role of HOX C13 in metastatic melanoma switch.

Open References

- Increased HOX C13 expression in metastatic melanoma progression. Cantile M, Scognamiglio G, Anniciello A, Farina M, Gentilcore G, Santonastaso C, Fulciniti F, Cillo C, Franco R, Ascierto PA, Botti G. J Transl Med. 2012 May 14;10:91. PMID: #22583695# [Free]