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PGK1

Sunday 30 December 2012

Pathology

- PGK1 could be a potential marker for peritoneal dissemination in gastric cancer. (18453750)

  • The overexpression of PGK1 and its signalling targets may be a expression-pathway in diffuse primary gastric carcinomas promoting peritoneal dissemination and may function as prognostic markers and/or be potential therapeutic targets to prevent the migration of gastric carcinoma cells into the peritoneum.
  • Peritoneal carcinomatosis, which is caused by the dissemination of cancer cells into the abdominal cavity is a frequent finding in patients with primary gastric cancer, and it is associated with a poor prognosis.
  • The mechanisms that mediate peritoneal carcinomatosis in diffuse primary gastric tumours require definition.

Reference

- PGK1 a potential marker for peritoneal dissemination in gastric cancer. Zieker D, Königsrainer I, Traub F, Nieselt K, Knapp B, Schillinger C, Stirnkorb C, Fend F, Northoff H, Kupka S, Brücher BL, Königsrainer A. Cell Physiol Biochem. 2008;21(5-6):429-36. PMID: 18453750