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urine cell-free DNA

Monday 31 December 2012

urine cell-free DNA; cell-free DNA in urine, UCF DNA; urine cell free DNA

Urine cell-free (UCF) DNA has recently been proposed as a potential marker for early bladder cancer diagnosis.

It is known that normal apoptotic cells produce highly fragmented DNA while cancer cells release longer DNA.

Therefore, the potential role of UCF DNA integrity in early bladder cancer diagnosis has been verified. (23141783)

Preliminary data suggest that UCF DNA integrity is a potentially good marker for early noninvasive diagnosis of bladder cancer. (23141783)

Its diagnostic performance does not seem to vary significantly, even in an "at risk" population of symptomatic individuals. (23141783)


- The potential use of urine cell free DNA as a marker for cancer. Salvi S, Martignano F, Molinari C, Gurioli G, Calistri D, De Giorgi U, Conteduca V, Casadio V. Expert Rev Mol Diagn. 2016 Oct 31. PMID: 27796148

- Urine Cell-Free DNA integrity as a marker for early bladder cancer diagnosis: Preliminary data. Casadio V, Calistri D, Tebaldi M, Bravaccini S, Gunelli R, Martorana G, Bertaccini A, Serra L, Scarpi E, Amadori D, Silvestrini R, Zoli W. Urol Oncol. 2012 Nov 7. PMID: 23141783