colorectal neural lesions
Monday 31 December 2012
Neural lesions of the colon
Neural lesions of the colon are a rare group of colorectal disorders that may frequently present as small polyps.
This heterogeneous group includes ganglion cells and nerve sheath tumors that have been frequently described as multiple lesions in association with inherited syndrome such as:
von Recklinghausen (or type 1) neurofibromatosis (NF-1),
multiple endocrine neoplasia type 2B (MEN 2B),
Moreover, sporadic forms of these neural lesions have been reported including:
solitary colonic polypoid ganglioneuroma,
solitary colonic neurofibroma,
mucosal benign epithelioid nerve sheath tumors.
Recently, Gibson and Hornick have analysed 26 cases of colorectal polypoid lesions comprising pure Schwann cell proliferation, which were different from gastrointestinal tract (GI) schwannomas, and with no association with inherited syndromes. This entity was designated as mucosal Schwann cell hamartoma .
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