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mammary tubular adenoma

Thursday 3 January 2013

tubular adenoma of the breast



- Breast: Tubular Adenoma : tubules without atypia in a moto perpetuo pattern


Definition: Tubular adenoma of the breast presents as a solitary, circumscribed, firm mass. Tubular adenoma of the breast is composed of closely packed small tubules lined by a layer of epithelial cells surrounded by myoepithelial layer.


Tubular adenoma of the breast may be related to the fibroadenoma since the two sometimes coexist. Both components are conspicuous and are at least 10% of the lesion.


- Rare. Usually young women, occasionally older women (Breast Cancer 2000;7:169)
- Solitary, well-circumscribed, tan-yellow, soft to firm mass.
- Benign nodules formed by the compact proliferation of tubular structures with 2 cell layers.
- Closely packed uniform small tubules lined by single layer of epithelial cells and attenuated myoepithelium; sparse stroma.
- May have lymphocytic infiltrate, no atypia


- EMA+
- ER+, PR+

- Myoepithelial cells

  • Smooth muscle actin SMA+
  • vimentin + (Pathol Res Pract 1995;191:1222)

Differential diagnosis

- Adenomyoepithelioma, tubular variant

  • prominent myoepithelium, not well circumscribed

- Fibroadenoma

  • more stroma, less epithelium

- Infiltrating ductal carcinoma

  • irregular tubules, atypia, desmoplasia, infiltrative


- Excision, does not recur.



See also

- mammary tumors