Links Chronic berylliosis (Contributed by...
Monday 11 February 2013
Chronic berylliosis (Contributed by Philip Kane, MD) (Yale Rosen Collection)
The microscopic features of chronic beryllium disease closely resemble those of sarcoiodosis. Peribronchial non-necrotizing granulomas are present.
There is nothing distinctive about the appearance of these granulomas that would enable one to make a diagnosis of beryllium disease with an occupational history and beryllium lymphocyte proliferation testing.
There is chronic interstitial inflammation and aggregates of inclusion-containing giant cells.
The unusual inclusions seen in these giant cells appear to be cholesterol crystals with a peripheral rim of calcification.
Cholesterol crystals can apparently serve as a nidus for calcification just as calcium carbonate crystals can serve as a nidus for the formation of calcific Schaumann (conchoidal) bodies.