Links Chronic berylliosis (Contributed by...
Monday 11 February 2013
Chronic berylliosis (Contributed by Philip Kane, MD) (Yale Rosen Collection)
The microscopic features of chronic beryllium disease closely resemble those of sarcoiodosis. Peribronchial non-necrotizing granulomas are present.
There is nothing distinctive about the appearance of these granulomas that would enable one to make a diagnosis of beryllium disease with an occupational history and beryllium lymphocyte proliferation testing.
The unusual inclusions seen in these giant cells appear to be cholesterol crystals with a peripheral rim of calcification.