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LIMs

Tuesday 25 November 2003

LIM proteins contain a highly conserved double zinc finger motif called the LIM domain. LIM genes constitute a large gene family whose gene products carry the LIM domain, a unique cysteine-rich zinc-binding domain.

At least 40 members of this family have been identified in vertebrates and invertebrates, and are distributed into 4 groups according to the number of LIM domains and to the presence of domains such as homeodomains and kinase domains.

LIM-homeodomain proteins are characterized by the presence of 2 tandem cysteine/histidine-rich, zinc-binding LIM domains.

Members

LHXs LHX1 LHX2 LHX3 LHX4 LHX5 LHX6 LHX7 LHX8 LHX9
LMXs LMX1A LMX1B
LMOs LMO1 LMO2 LMO3 LMO4 LMO5 LMO6 LMO7
FHLs FHL1 FHL2 FHL3

Pathology

- LMX1B germline mutations in nail-patella syndrome

See also

- transcription factors

References

- Hobert O, Westphal H. Functions of LIM-homeobox genes. Trends Genet. 2000 Feb;16(2):75-83. PMID: 10652534