multinucleate epithelial change in colorectal hyperplastic polyp
Tuesday 30 April 2013
Multinucleate epithelial change in colorectal hyperplastic polyps
Hyperplastic polyps containing multinucleated epithelial giant cells (MEGs) show active inflammation and apoptosis, and in most there was also focal inflammation and apoptosis in the adjacent mucosa.
Inflammation in conjunction with the increased epithelial proliferation characteristics of hyperplastic polyps could be the mechanism for the MEG formation.
Multinucleated epithelial giant cells in colorectal polyps: a potential mimic of viropathic and/or dysplastic changes. Kambham N, Troxell M, Longacre TA. Am J Surg Pathol. 2005 Jul;29(7):912-9. PMID: 15958856