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DNA repair capacity

Monday 3 June 2013


DNA repair capacity (DRC) is a determinant not only of cancer development but also of individual response to therapy.

Altered base and nucleotide excision repair (BER and NER) have been described in lymphocytes of patients with sporadic colorectal cancer.

A study shows the feasibility of DRC evaluation in human solid tissues, representing a complex marker of multigene DNA repair processes.


- Functional, genetic, and epigenetic aspects of base and nucleotide excision repair in colorectal carcinomas. Slyskova J, Korenkova V, Collins AR, Prochazka P, Vodickova L, Svec J, Lipska L, Levy M, Schneiderova M, Liska V, Holubec L, Kumar R, Soucek P, Naccarati A, Vodicka P. Clin Cancer Res. 2012 Nov 1;18(21):5878-87. doi : 10.1158/1078-0432.CCR-12-1380 PMID: 22966016