multifocal thyroid papillary carcinoma
Wednesday 26 June 2013
Papillary thyroid carcinoma (PTC) is frequently multifocal, which can represent either intraglandular spread from a single primary tumor or multiple synchronous primary tumors (MSPTs).
At least 30% of multifocal PTCs represent unequivocal MSPTs that develop through distinct molecular alterations and that as many as 60% of multifocal PTCs are likely MSPTs.
Histopathologically, MSPTs are typically located in different lobes, have distinct growth patterns, and do not show microscopic peritumoral dissemination.
Molecular and Histopathologic Characteristics of Multifocal Papillary Thyroid Carcinoma. Bansal M, Gandhi M, Ferris RL, Nikiforova MN, Yip L, Carty SE, Nikiforov YE. Am J Surg Pathol. 2013 Jun 20. PMID: 23797723