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congenital CMV infection

Wednesday 26 June 2013

Congenital cytomegalovirus (CMV) infection may be asymptomatic until hearing loss manifests in childhood.

Images

- Congenital CMV chorionitis

PCR diagnosis from FFPE

Because diagnosis of congenital CMV requires viral detection within an infant’s first 21 days of life, CMV polymerase chain reaction (PCR) on formalin-fixed, paraffin-embedded (FFPE) placental tissue provides a unique opportunity to identify congenital exposure in cases in which CMV is not initially suspected.

The confirmation of CMV exposure in utero by PCR of FFPE placental tissue provides a useful adjunct to histologic evaluation and may identify infants requiring close clinical follow-up.

Diagnosis of Congenital CMV Using PCR Performed on Formalin-fixed, Paraffin-embedded Placental Tissue.

Reference

- Folkins AK, Chisholm KM, Guo FP, McDowell M, Aziz N, Pinsky BA. Am J Surg Pathol. 2013 Jun 20. PMID: 23797721