mucinous carcinomas with associated ovarian teratoma
Friday 5 July 2013
The tissue derivation of mucinous ovarian carcinoma remains a mystery; however, rare tumors are associated with mature teratoma. Studies of chromosomal heteromorphisms and DNA polymorphisms proved that ovarian teratomas arise during female gametogenesis.
Microsatellite polymorphism analysis demonstrates that mucinous ovarian carcinomas usually clonally match associated teratomas when present and often show evidence of complete isodisomy, indicating that at least some mucinous carcinomas arise from female gametes and thus are of germ cell origin.
The zygosity patterns in mucinous carcinomas without teratoma suggest that these tumors may arise through a different mechanism.
Matching Maternal Isodisomy in Mucinous Carcinomas and Associated Ovarian Teratomas Provides Evidence of Germ Cell Derivation for Some Mucinous Ovarian Tumors. Kerr SE, Flotte AB, McFalls MJ, Vrana JA, Halling KC, Bell DA. Am J Surg Pathol. 2013 Jun 14. PMID: 23774174