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EWSR1-associated tumors

Monday 15 July 2013

Tumors (examples)

- Ewing group of tumors

  • Ewing sarcoma
  • pPNET

- clear cell odontogenic carcinoma (#23715163#)

  • Clear cell odontogenic carcinomas (CCOCs) are a rare tumor of the jaws, which have considerable morphologic and immunophenotypic overlap with (hyalinizing) clear cell carcinomas (CCCs) of salivary origin.
  • Some studies demonstrate the EWSR1-ATF1 translocation in a CCOC and demonstrate a concrete link between CCCs and at least a subset of CCOCs. (#23715163#)

References

- Clear Cell Odontogenic Carcinomas Show EWSR1 Rearrangements: A Novel Finding and a Biological Link to Salivary Clear Cell Carcinomas. Bilodeau EA, Weinreb I, Antonescu CR, Zhang L, Dacic S, Muller S, Barker B, Seethala RR. Am J Surg Pathol. 2013 Jul;37(7):1001-5. doi:10.1097/PAS.0b013e31828a6727 . PMID: #23715163#