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peripheral T-cell lymphomas of follicular T-helper cell derivation with Hodgkin/Reed-Sternberg cells of B-cell lineage

Wednesday 24 July 2013

Peripheral T-cell lymphomas of follicular T-helper cell derivation with Hodgkin/Reed-Sternberg cells of B-cell lineage; Follicular peripheral T-cell lymphoma with HRS

Peripheral T-cell lymphomas (PTCLs) are functionally and morphologically complex.

Microscopical synopsis

- HRS-like B cells (#23598959#)

  • Both EBV-positive and EBV-negative HRS-like B cells may occur in the background of PTCL.
  • Caution is needed to avoid misdiagnosis as classical Hodgkin lymphoma.
  • The close interaction between the HRS-like cells and the rosetting PD-1-positive T cells suggests a possible pathogenetic role in this phenomenon and provides new insights into the abnormal B-cell proliferations that occur in the context of TFH malignancies.

- Epstein-Barr virus (EBV)-positive B cells and EBV-positive HRS-like B cells (#23598959#)

  • Epstein-Barr virus (EBV)-positive B cells have been reported in angioimmunoblastic T-cell lymphoma (AITL) and other PTCLs and may mimic Hodgkin/Reed-Sternberg (HRS) cells, but EBV-negative HRS-like B cells have not been described.

References

- Peripheral T-cell lymphomas of follicular T-helper cell derivation with Hodgkin/Reed-Sternberg cells of B-cell lineage: both EBV-positive and EBV-negative variants exist. Nicolae A, Pittaluga S, Venkataraman G, Vijnovich-Baron A, Xi L, Raffeld M, Jaffe ES. Am J Surg Pathol. 2013 Jun;37(6):816-26. doi:10.1097/PAS.0b013e3182785610 . PMID: #23598959#

- Follicular peripheral T-cell lymphoma expands the spectrum of classical Hodgkin lymphoma mimics. Moroch J, Copie-Bergman C, de Leval L, Plonquet A, Martin-Garcia N, Delfau-Larue MH, Molinier-Frenkel V, Belhadj K, Haioun C, Audouin J, Swerdlow SH, Marafioti T, Gaulard P. Am J Surg Pathol. 2012 Nov;36(11):1636-46. doi:10.1097/PAS.0b013e318268d9ff . PMID: #23073322#

- Peripheral T-cell lymphoma with Reed-Sternberg-like cells of B-cell phenotype and genotype associated with Epstein-Barr virus infection. Quintanilla-Martinez L, Fend F, Moguel LR, Spilove L, Beaty MW, Kingma DW, Raffeld M, Jaffe ES. Am J Surg Pathol. 1999 Oct;23(10):1233-40. PMID: #10524524#