Sunday 5 January 2014
Cancer cells contain multiple genetic and epigenetic abnormalities. Despite this complexity, their growth and survival can often be impaired by the inactivation of a single oncogene. This phenomenon, called "oncogene addiction," provides a rationale for molecular targeted therapy.
Combination therapy may also be required to prevent the escape of cancers from a given state of oncogene addiction.
Mechanisms of disease: Oncogene addiction—a rationale for molecular targeting in cancer therapy. Weinstein IB, Joe AK. Nat Clin Pract Oncol. 2006 Aug;3(8):448-57. Review. PMID: 16894390
Cancer. Addiction to oncogenes—the Achilles heal of cancer. Weinstein IB. Science. 2002 Jul 5;297(5578):63-4. PMID: 12098689