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mediastinal extramedullary hematopoietic tumor

Monday 16 September 2013

mediastinal reactive extramedullary hematopoietic tumors; thoracic extramedullary hematopoiesis

"Reactive extramedullary hematopoietic tumors that usually occur in patients with severe chronic anemias.

Patients with extramedullary hematopoietic tumors are characterized by anemia, frequent hepatosplenomegaly and abnormal peripheral blood smears, and may be any age.

The tumors are usually multiple and usually located in the mediastinum or epidural space.

Associations

- hereditary spherocytosis (23614106)
- beta-thalassanemia (16584618, 2353310, 598999)
- sickle-cell disease (14755765, 8031567)
- hemoglobin C (8639058)
- markedly hypocellular bone marrow (16682520)

Differential diagnosis

Patients with extra-adrenal myelolipomas are usually older than 40 years, have normal blood studies, absent hepatosplenomegaly, and usually have chronic debilitating diseases or endocrinopathies.

Open references

- Extramedullary hematopoiesis at the posterior mediastinum in patient with hereditary spherocytosis: a case report. Yeom SY, Lim JH, Han KN, Kang CH, Park IK, Kim YT.
Korean J Thorac Cardiovasc Surg. 2013 Apr;46(2):156-8. doi : 10.5090/kjtcs.2013.46.2.156 PMID: 23614106 [Free]

- A case report: thoracic extramedullary hematopoiesis found by occurring spontaneous pneumothorax. Kubokura H, Koizumi K, Yoshino N, Yamagishi S, Mikami I, Hirata T, Harada A, Kawamoto M, Shimizu K. Ann Thorac Cardiovasc Surg. 2008 Dec;14(6):382-5. PMID: 19131925 [Free]

- Video-assisted thoracoscopic surgery for intrathoracic extramedullary hematopoiesis. Giblin E, Frankel K, Mortman K. J Minim Access Surg. 2007 Jan;3(1):32-4. doi : 10.4103/0972-9941.30685 PMID: 20668617 [Free]