microsatellite-stable colorectal cancer
Saturday 12 October 2013
In MSS CRC, genetic alterations occurring early in CRC carcinogenesis are remarkably stable during metastatic progression, indicating:
(i) a very low degree of genetic heterogeneity between primary and multiple secondary sites with respect to CRC driver mutations and
(ii) that genetic interrogation of archived primary tumor samples appears to be sufficient for the application of cancer precision medicine in the metastatic setting (25786087).
Distinctive Spatiotemporal Stability of Somatic Mutations in Metastasized Microsatellite-stable Colorectal Cancer. Jesinghaus M, Wolf T, Pfarr N, Muckenhuber A, Ahadova A, Warth A, Goeppert B, Sers C, Kloor M, Endris V, Stenzinger A, Weichert W. Am J Surg Pathol. 2015 Mar 16. PMID: 25786087
Complex patterns of altered MicroRNA expression during the adenoma-adenocarcinoma sequence for microsatellite-stable colorectal cancer. Bartley AN, Yao H, Barkoh BA, Ivan C, Mishra BM, Rashid A, Calin GA, Luthra R, Hamilton SR. Clin Cancer Res. 2011 Dec 1;17(23):7283-93. doi : 10.1158/1078-0432.CCR-11-1452 PMID: 21948089 [Free]