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microsatellite-stable colorectal cancer

Saturday 12 October 2013

In MSS CRC, genetic alterations occurring early in CRC carcinogenesis are remarkably stable during metastatic progression, indicating:
- (i) a very low degree of genetic heterogeneity between primary and multiple secondary sites with respect to CRC driver mutations and
- (ii) that genetic interrogation of archived primary tumor samples appears to be sufficient for the application of cancer precision medicine in the metastatic setting (25786087).

References

- Distinctive Spatiotemporal Stability of Somatic Mutations in Metastasized Microsatellite-stable Colorectal Cancer. Jesinghaus M, Wolf T, Pfarr N, Muckenhuber A, Ahadova A, Warth A, Goeppert B, Sers C, Kloor M, Endris V, Stenzinger A, Weichert W. Am J Surg Pathol. 2015 Mar 16. PMID: 25786087

- Complex patterns of altered MicroRNA expression during the adenoma-adenocarcinoma sequence for microsatellite-stable colorectal cancer. Bartley AN, Yao H, Barkoh BA, Ivan C, Mishra BM, Rashid A, Calin GA, Luthra R, Hamilton SR. Clin Cancer Res. 2011 Dec 1;17(23):7283-93. doi : 10.1158/1078-0432.CCR-11-1452 PMID: 21948089 [Free]