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CRTC3-MAML2 - Humpath.com - Human pathology

Home > A. Molecular pathology > Fusion genes > CRTC3-MAML2

CRTC3-MAML2

Monday 14 October 2013

MAML2-CRTC3

Pathology

- mucoepidermoid carcinoma

  • The recurrent translocations t(11;19) and t(11;15) resulting in CRTC1-MAML2 or CRTC3-MAML2 fusion oncogenes, respectively, are identified in a large proportion of mucoepidermoid carcinomas (MECs) of the salivary gland and have impact on prognosis.

- Warthin tumor

  • Its putative occurrence in Warthin tumor (WT) of the parotid gland has been reported in few previous cases.
  • It was speculated that extensive squamous metaplasia could explain the presence of t(11;19) translocation in a subset of WTs.
  • CRTC1-MAML2 and CRTC3-MAML2 Fusions has not been detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands. ( doi : 10.1097/PAS 0000000000000065 )

References

- CRTC1-MAML2 and CRTC3-MAML2 Fusions Were Not Detected in Metaplastic Warthin Tumor and Metaplastic Pleomorphic Adenoma of Salivary Glands. 2013. doi : 10.1097/PAS 0000000000000065