respiratory epithelial adenomatoid hamartoma
Monday 14 October 2013
Respiratory epithelial adenomatoid hamartoma (REAH)
Definition: Respiratory epithelial adenomatoid hamartoma (REAH) is regarded as a rare tumor of the nasal cavity. The mechanisms driving the development of REAH are unknown, and its nature as a benign tumor, hamartoma, or reactive inflammatory process is still open to discussion.
If solitary REAH is a relatively rare lesion, it has been demonstrated that an exhaustive sampling allows the detection of a high proportion of nasal polyposis-associated REAH, sharing the same clinical and histologic characteristics with solitary REAH.
Tryptase-producing MCs, possibly in association with MMP expression, may play a central role in REAH formation.