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ITK

HGNC:6171 5q31-q32

Monday 14 October 2013

EMT, LYK, PSCTK2; IL2-inducible T-cell kinase

Open References

- The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease. Dierks C, Adrian F, Fisch P, Ma H, Maurer H, Herchenbach D, Forster CU, Sprissler C, Liu G, Rottmann S, Guo GR, Katja Z, Veelken H, Warmuth M. Cancer Res. 2010 Aug 1;70(15):6193-204. doi:10.1158/0008-5472.CAN-08-3719 . PMID: 20670954 [Free]

- The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. Pechloff K, Holch J, Ferch U, Schweneker M, Brunner K, Kremer M, Sparwasser T, Quintanilla-Martinez L, Zimber-Strobl U, Streubel B, Gewies A, Peschel C, Ruland J. J Exp Med. 2010 May 10;207(5):1031-44. doi:10.1084/jem.20092042 . PMID: 20439541 [Free]

- Peripheral T cell lymphoma: new model + new insight. Mulloy JC. J Exp Med. 2010 May 10;207(5):911-3. doi:10.1084/jem.20100608 . PMID: 20439538 [Free]

References

- ITK/SYK Translocation in Angioimmunoblastic T-cell Lymphoma. Attygalle AD, Feldman AL, Dogan A. Am J Surg Pathol. 2013 Sep;37(9):1456-7. doi:10.1097/PAS.0b013e3182991415 . PMID: #24076779#

- Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma. Streubel B, Vinatzer U, Willheim M, Raderer M, Chott A. Leukemia. 2006 Feb;20(2):313-8. PMID: #16341044#