Home > A. Molecular pathology > ITK

ITK

HGNC:6171 5q31-q32

Monday 14 October 2013

EMT, LYK, PSCTK2; IL2-inducible T-cell kinase

Open References

- The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease. Dierks C, Adrian F, Fisch P, Ma H, Maurer H, Herchenbach D, Forster CU, Sprissler C, Liu G, Rottmann S, Guo GR, Katja Z, Veelken H, Warmuth M. Cancer Res. 2010 Aug 1;70(15):6193-204. doi : 10.1158/0008-5472.CAN-08-3719 PMID: 20670954 [Free]

- The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. Pechloff K, Holch J, Ferch U, Schweneker M, Brunner K, Kremer M, Sparwasser T, Quintanilla-Martinez L, Zimber-Strobl U, Streubel B, Gewies A, Peschel C, Ruland J. J Exp Med. 2010 May 10;207(5):1031-44. doi : 10.1084/jem.20092042 PMID: 20439541 [Free]

- Peripheral T cell lymphoma: new model + new insight. Mulloy JC. J Exp Med. 2010 May 10;207(5):911-3. doi : 10.1084/jem.20100608 PMID: 20439538 [Free]

References

- ITK/SYK Translocation in Angioimmunoblastic T-cell Lymphoma. Attygalle AD, Feldman AL, Dogan A. Am J Surg Pathol. 2013 Sep;37(9):1456-7. doi : 10.1097/PAS.0b013e3182991415 PMID: 24076779

- Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma. Streubel B, Vinatzer U, Willheim M, Raderer M, Chott A. Leukemia. 2006 Feb;20(2):313-8. PMID: 16341044