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vulvar squamous cell carcinoma.

Monday 14 October 2013


- Stage 1a (24076774)

  • Invasive squamous cell carcinoma of the vulva with ≤1 mm stromal invasion is classified as stage 1A.
  • Cancer staging systems state that the depth of invasion should be measured from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of the invasive tumor.
  • Measurement of the depth of invasion guides patient management.
  • Even though this measurement is critical, no studies have reported the reliability among pathologists for determining the cutoff point of ≤1 mm stromal invasion in vulvar cancer.


- Interobserver Agreement for Assessing Invasion in Stage 1A Vulvar Squamous Cell Carcinoma. Abdel-Mesih A, Daya D, Onuma K, Sur M, Tang S, Akhtar-Danesh N, Boutross-Tadross O, Ceballos KM, Chapman W, Colgan T, Deb P, Nucci MR, Oliva E, Lytwyn A. Am J Surg Pathol. 2013 Sep;37(9):1336-41. doi : 10.1097/PAS.0b013e31829f306a PMID: 24076774