- Human pathology

Home > A. Molecular pathology > KIF5B


Sunday 5 January 2014


Definition: Kinesin-1 heavy chain is a protein that in humans is encoded by the KIF5B gene. KIF5B has been shown to interact with SNAP-25, SNAP23, KLC2, YWHAH and KLC1.


- fusion genes

Open references

- KIF5B-RET Fusion gene may coincide oncogenic mutations of EGFR or KRAS gene in lung adenocarcinomas. Kim JO, Lee J, Shin JY, Oh JE, Jung CK, Park JK, Sung SW, Bae SJ, Min HJ, Kim D, Park JY, Kang JH. Diagn Pathol. 2015 Aug 14;10:143. doi : 10.1186/s13000-015-0368-z PMID: 26268359


- Diagnostic method for the detection of KIF5B-RET transformation in lung adenocarcinoma. Go H, Jung YJ, Kang HW, Park IK, Kang CH, Lee JW, Ju YS, Seo JS, Chung DH, Kim YT. Lung Cancer. 2013 Oct;82(1):44-50. doi : 10.1016/j.lungcan.2013.07.009 PMID: 23932363

- KIF5B/RET fusion gene analysis in a selected series of cytological specimens of EGFR, KRAS and EML4-ALK wild-type adenocarcinomas of the lung. Borrelli N, Giannini R, Proietti A, Alì G, Pelliccioni S, Niccoli C, Lucchi M, Melfi F, Mussi A, Basolo F, Fontanini G. Lung Cancer. 2013 Sep;81(3):377-81. doi : 10.1016/j.lungcan.2013.06.026 PMID: 23891510