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ovarian serous borderline tumor

Thursday 9 January 2014

Atypical proliferating serous tumors

PO

Images

- http://www.webpathology.com/image.asp?n=24&Case=525
- Wikimedia: serous borderline tumor with micropapillary pattern

- Ovarian serous borderline tumor with focal microinvasion

Differential diagnosis

- benign serous papillary cystadenoma

  • may have focal areas of atypia suggestive, but not diagnostic of borderline tumor

- serous carcinoma

  • low grade tumors may have similar appearance, but have destructive stromal invasion

- mucinous borderline tumors

  • epithelium is mucinous;
  • mixed tumors have mucinous, squamous or endometrioid differentiation, often associated with endometriosis

- ovarian clear cell carcinoma

  • may have papillary features, but are unilateral, associated with endometriosis;
  • have nonhierarchical branching, monomorphic cells with classic features elsewhere, focal cytologic atypia (Am J Surg Pathol 2008;32:269)

See also

- ovarian tumors

Reference

- Molecular subtypes of serous borderline ovarian tumor show distinct expression patterns of benign tumor and malignant tumor-associated signatures. Curry EW, Stronach EA, Rama NR, Wang YY, Gabra H, El-Bahrawy MA. Mod Pathol. 2013 Aug 16. doi : 10.1038/modpathol.2013.130 PMID: 23948749