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STAT6

Tuesday 24 June 2014

IHC marker

- STAT6 overexpression in solitary fibrous tumors (SFTs). (24625420)

Pathology

- Amplification

- NAB2-STAT6 gene fusion

Open references

- A GRIA2 and PAX8-positive renal solitary fibrous tumor with NAB2-STAT6 gene fusion. Ichiyanagi O, Ito H, Takai S, Naito S, Kato T, Nagaoka A, Yamakawa M. Diagn Pathol. 2015 Sep 4;10(1):155. doi : 10.1186/s13000-015-0386-x PMID: 26337721 (Free)

- STAT6 is amplified in a subset of dedifferentiated liposarcoma. Doyle LA, Tao D, Mariño-Enríquez A. Mod Pathol. 2014 Jan 24. doi : 10.1038/modpathol.2013.247 PMID: 24457460 (Free)

- Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. Robinson DR, Wu YM, Kalyana-Sundaram S, Cao X, Lonigro RJ, Sung YS, Chen CL, Zhang L, Wang R, Su F, Iyer MK, Roychowdhury S, Siddiqui J, Pienta KJ, Kunju LP, Talpaz M, Mosquera JM, Singer S, Schuetze SM, Antonescu CR, Chinnaiyan AM. Nat Genet. 2013 Feb;45(2):180-5. doi : 10.1038/ng.2509 PMID: 23313952 [Free]

References

References

- Analysis of NAB2-STAT6 Gene Fusion in 17 Cases of Meningeal Solitary Fibrous Tumor/Hemangiopericytoma: Review of the Literature. Yuzawa S, Nishihara H, Wang L, Tsuda M, Kimura T, Tanino M, Tanaka S. Am J Surg Pathol. 2016 Feb 26. PMID: 26927892

- NAB2-STAT6 Gene Fusion in Meningeal Hemangiopericytoma and Solitary Fibrous Tumor. Fritchie KJ, Jin L, Rubin BP, Burger PC, Jenkins SM, Barthelmeß S, Moskalev EA, Haller F, Oliveira AM, Giannini C. J Neuropathol Exp Neurol. 2016 Feb 16. pii: nlv026. PMID: 26883114

- STAT6 immunohistochemistry is helpful in the diagnosis of solitary fibrous tumors. Yoshida A, Tsuta K, Ohno M, Yoshida M, Narita Y, Kawai A, Asamura H, Kushima R.
Am J Surg Pathol. 2014 Apr;38(4):552-9. doi : 10.1097/PAS.0000000000000137 PMID: 24625420