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prostatic glandular proliferation

Friday 18 March 2016

glandular proliferations in the prostate

A variety of small acinar lesions of the prostate can mimic prostate cancer in punch biopsies and in transurethral resection material.

Differential diagnostic problems are seen in the central and transition zone, including:
- atypical adenomatous hyperplasia of the prostate,
- atrophic processes,
- sclerosing adenosis,
- basal cell hyperplasia,
- low-grade adenocarcinoma.

Differential diagnostic problems also occur in the peripheral zone between:
- prostatic intraepithelial neoplasia (PIN),
- post-atrophic hyperplasia,
- Cowper’s glands,
- seminal vesicles,
- ductal and intraductal carcinoma.

Atypical and small acinar proliferations can also been described.


- Differential diagnosis of glandular proliferations in the prostate. A conventional and immunohistochemical approach. Helpap B. Virchows Arch. 1998 Nov;433(5):397-405. PMID: 9849853