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miR-148

Monday 14 September 2015

miR-148a and miR-148b

WKP

miR-148 is a microRNA whose expression has been demonstrated in human (MI0000253), mouse (MI0000550), rat (MI0000616) and zebrafish (MI0002015). miR-148 has also been predicted in chicken (MI0001189).

These predicted hairpin precursor sequence are related to those of miR-152, which has been expressed in mouse (MI0000174) and is predicted in human (MI0000462).[1]

The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known. In this case, the mature sequence is excised from the 3’ arm of the hairpin.

Targets

MicroRNAs act by lowering the expression of genes by binding to target sites in the 3’ UTR of the mRNAs. However recently it was shown by Duursma and colleagues that miR-148 down regulates Dnmt3b by binding to a region in the protein coding region

Pathology

- Decrease expression and clinicopathological significance of miR-148a with poor survival in hepatocellular carcinoma tissues. (26248880)

  • Down-regulation of miR-148a is related to HCC carcinogenesis and deterioration of HCC.
  • MicroRNA-148a may act as a suppressor miRNA of HCC.
  • It is therefore a potential prognostic biomarker for HCC patients.

- Down-regulated MicroRNA 148b expression is predictive biomarker. (26377406)

  • Its prognostic significance associated with clinicopathological features in non-small-cell lung cancer patients. (26377406)
  • miR-148b may play a role as independent prognostic factor for patients with NSCLC.

Open references

- Down-regulated MicroRNA 148b expression as predictive biomarker and its prognostic significance associated with clinicopathological features in non-small-cell lung cancer patients. Ghasemkhani N, Shadvar S, Masoudi Y, Talaei AJ, Yahaghi E, Goudarzi PK, Shakiba E. Diagn Pathol. 2015 Sep 17;10(1):164. doi : 10.1186/s13000-015-0393-y PMID: 26377406 (Free)

- Decrease expression and clinicopathological significance of miR-148a with poor survival in hepatocellular carcinoma tissues. Ajdarkosh H, Dadpay M, Yahaghi E, Pirzaman ER, Fayyaz AF, Darian EK, Mokarizadeh A. Diagn Pathol. 2015 Aug 7;10:135. doi : 10.1186/s13000-015-0371-4 PMID: 26248880 (Free)