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tumor mutational burden

Wednesday 13 April 2016

tumor mutational load; TMB


- Johnson et al. Targeted next generation sequencing identifies markers of response to PD-1 blockade. Cancer Immunology Research. 2016. doi : 10.1158/2326-6066.CIR-16-0143

- Rizvi et al. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science. 2015;348(6230):124-128.

- Reliable Detection of Mismatch Repair Deficiency in Colorectal Cancers Using Mutational Load in Next-Generation Sequencing Panels. Stadler ZK, Battaglin F, Middha S, Hechtman JF, Tran C, Cercek A, Yaeger R, Segal NH, Varghese AM, Reidy-Lagunes DL, Kemeny NE, Salo-Mullen EE, Ashraf A, Weiser MR, Garcia-Aguilar J, Robson ME, Offit K, Arcila ME, Berger MF, Shia J, Solit DB, Saltz LB. J Clin Oncol. 2016 Mar 28. pii: JCO651067. PMID: 27022117