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nuclear pseudoinclusions

Tuesday 10 May 2016

Nuclear pseudoinclusion

Definition: Nuclear pseudoinclusions represent invaginations of cytoplasm into the nucleus.


Intranuclear cytoplasmic inclusions

- Intranuclear cytoplasmic inclusions in paraganglioma

- Dutcher bodies (nuclear pseudo-inclusions) in plasma cell myeloma

They are delimited by the nuclear membrane. Although not totally specific, they are particularly common in papillary thyroid carcinoma, meningioma, and usual ductal hyperplasia of the breast and hence may aid in the diagnosis of these entities.

Nuclear pseudo-pseudoinclusions, which are artefactual bubbles in the nuclei that mimic nuclear pseudoinclusions or clear nuclei, can lead to misdiagnosis of follicular adenoma or hyperplastic nodule as papillary thyroid carcinoma.

See also

- cellular inclusions

- microscopical anomalies


- Nuclear inclusions and pseudoinclusions: friends or foes of the surgical pathologist? Ip YT, Dias Filho MA, Chan JK. Int J Surg Pathol. 2010 Dec;18(6):465-81. doi : 10.1177/1066896910385342 PMID: 21081532