Humpath.com - Human pathology

Home > A. Molecular pathology > CD40

CD40

Wednesday 15 June 2016

WP

Definition: CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L coded by CD40LG ) on T Helper cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.

Pathology

Deficiency in CD40 can cause Hyper-IgM syndrome type 3.

Targeted therapy

- CD40 agonists

  • - CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer.
    (27292635)

References

- CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer.
Byrne KT, et al. Cell Rep. 2016. PMID: 27292635