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salivary acinic cell carcinoma

Saturday 2 July 2016


Definition: Acinic cell carcinoma is an encapsulated carcinoma that shows cells with basophilic granular cytoplasm filled with PAS positive zymogen granules, is positive for amylase, and has a prominent lymphocytic infiltrate. It is most common in the parotid and minor salivary glands.



- Acinic cell carcinoma with tumor associated lymphoid response (not a lymph node metastasis)

- salivary acinic cell carcinoma with high grade transformation (comedo necrosis)

- FNA : salivary acinic cell carcinoma


Cell Types: Acinic cell carcinomas are composed of an admixture of different cell types, including :
- a) acinar cells which are large polygonal cells with abundant basophilic granular cytoplasm (due to zymogen-like granules) and eccentrically placed small hyperchromatic nuclei;
- b) clear or vacuolated cells;
- c) intercalated duct-like cells which are cuboidal or columnar cells with eosinophilic or amphophilic cytoplasm (no zymogen-like granules) and centrally-placed small dark nuclei;
- d) non-specific glandular cells with eosinophilic cytoplasm and vesicular nuclei.

Histologic Patterns: The tumor cells display a variety of growth patterns such as solid pattern , follicular pattern , microcystic pattern , and papillary cystic pattern.

Solid and microcystic patterns are the most common and are often seen together.

See also

- salivary gland tumors

- acinic cell carcinoma