Monday 1 December 2003
Hormonal stimulation of cyclic adenosine monophosphate (cAMP) and the cAMP-dependent protein kinase PKA regulates cell growth by multiple mechanisms.
A hallmark of cAMP is its ability to stimulate cell growth in many cell types while inhibiting cell growth in others.
cAMP-dependent PKA pathway
cell type-specific effects of cAMP on the mitogen-activated protein (MAPs) kinase (extracellular signal-regulated kinase, or ERK) cascade and cell proliferation
activation of the GTPase Rap1
Stork PJ, Schmitt JM. Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends Cell Biol. 2002 Jun;12(6):258-66. PMID: 12074885