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cAMP

Monday 1 December 2003

Function

Hormonal stimulation of cyclic adenosine monophosphate (cAMP) and the cAMP-dependent protein kinase PKA regulates cell growth by multiple mechanisms.

A hallmark of cAMP is its ability to stimulate cell growth in many cell types while inhibiting cell growth in others.

See also

- cAMP-dependent PKA pathway
- cell type-specific effects of cAMP on the mitogen-activated protein (MAPs) kinase (extracellular signal-regulated kinase, or ERK) cascade and cell proliferation
- activation of the GTPase Rap1

References

- Stork PJ, Schmitt JM. Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends Cell Biol. 2002 Jun;12(6):258-66. PMID: 12074885