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Thursday 29 September 2016


Definition: Karyorrhexis is the destructive fragmentation of the nucleus of a dying cell whereby its chromatin is distributed irregularly throughout the cytoplasm.

It is usually preceded by pyknosis and can occur as a result of either programmed cell death (apoptosis ), senescence, or necrosis .

In apoptosis , the cleavage of DNA is done by Ca2+ and Mg2+ -dependent endonucleases.


- karyorrhexis of polymophonuclear cells

See also

- nuclear anomalies