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EGFR-Del19

Monday 10 October 2016

Exon 19 deletions

Definition: EGFR-Del19 are exon 19 deletions.

Open references

- Comparing overall survival between first generation EGFR-TKIs and chemotherapy in lung cancer patients with Del19/L858R.
Deng W, Lei Y, Liu S, Yang J, Tu H, Yan H, Wu Y.
Chin J Cancer Res. 2016 Jun;28(3):339-47.
doi : 10.21147/j.issn.1000-9604.2016.03.08
PMID: 27478319

- Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells.
Wu H, Wang A, Zhang W, Wang B, Chen C, Wang W, Hu C, Ye Z, Zhao Z, Wang L, Li X, Yu K, Liu J, Wu J, Yan XE, Zhao P, Wang J, Wang C, Weisberg EL, Gray NS, Yun CH, Liu J, Chen L, Liu Q.
Oncotarget. 2015 Oct 13;6(31):31313-22. doi : 10.18632/oncotarget.5182
PMID: 26375053