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AKT1-E17K

Monday 31 October 2016

AKT1E17K

AKT1

Phosphoinositide 3-kinases (PI3Ks) generate specific inositol lipids implicated in the regulation of cell growth, proliferation, survival, differentiation, and cytoskeletal changes. One of the best characterized targets of PI3K lipid products are AKTs (AKT1 and AKT2) (protein kinases B or PKBs).

The serine/threonine protein kinase AKT1 (also known as PKB, protein kinase B) is thought to be a key mediator of signal transduction processes. The identification of AKT1 substrates and the role AKT1 phosphorylation plays in regulating these molecules have been a major focus of research in recent years.

AKT1 plays a key role in cancer progression by stimulating cell proliferation and inhibiting apoptosis and is also probably a key mediator of insulin signalling.

Pathology

- Mutations in Ciliated muconodular papillary tumors (CMPTs)

  • Ciliated muconodular papillary tumors (CMPTs) are rare peripheral lung lesions, characterized by papillary architecture and ciliated columnar cells admixed with mucinous cells and basal cells.
  • A study identified 2 pathogenic mutations (BRAF-V600E and AKT1-E17K ). These data confirm BRAF V600E mutation as a probable driver in a subset of these tumors, along with AKT1 mutation, which further supports that CMPT are indolent pulmonary neoplasms.

See also

- AKTs

  • AKT1
  • AKT2

Paywall references

- Ciliated Muconodular Papillary Tumors of the Lung Can Occur in Western Patients and Show Mutations in BRAF and AKT1. Liu L, Aesif SW, Kipp BR, Voss JS, Daniel S, Aubry MC, Boland JM. Am J Surg Pathol. 2016 Jul 22. PMID: 27454941