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NCOA2

Monday 31 October 2016

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Pathology

- NCOA2 gene rearrangements

  • sclerozing rhabdomyosarcoma (ScRMS) and spindle cell rhabdomyosarcoma (SRMS) of infants
  • sclerosing rhabdomyosarcoma (ScRMS) and spindle cell rhabdomyosarcoma (SRMS) have been recently reclassified as a stand-alone pathologic entity, separate from embryonal RMS.
  • Tumors occurring in older children or adults harbor MYOD1 gene mutations with or without coexisting PIK3CA mutations.

- RHOH-NCOA2 ( AHRR-NCOA2 ) gene fusion in soft tissue angiofibroma (22337624)

- HEY1-NCOA2 Gene Fusion in mesenchymal chondrosarcoma (27544802)

  • between HEY1 and NCOA2

- Novel MEIS1-NCOA2 gene fusions define a distinct primitive spindle cell sarcoma of the kidney. (30179902)

Open references

- Chromosome aberrations and HEY1-NCOA2 fusion gene in a mesenchymal chondrosarcoma. Panagopoulos I, Gorunova L, Bjerkehagen B, Boye K, Heim S.
Oncol Rep. 2014 Jul;32(1):40-4. doi : 10.3892/or.2014.3180
PMID: 24839999

- A Molecular Study of Pediatric Spindle and Sclerosing Rhabdomyosarcoma: Identification of Novel and Recurrent VGLL2-related Fusions in Infantile Cases. Alaggio R, Zhang L, Sung YS, Huang SC, Chen CL, Bisogno G, Zin A, Agaram NP, LaQuaglia MP, Wexler LH, Antonescu CR. Am J Surg Pathol. 2016 Feb;40(2):224-35. doi : 10.1097/PAS.0000000000000538 PMID: 26501226 Free

- Chromosome aberrations and HEY1-NCOA2 fusion gene in a mesenchymal chondrosarcoma. Panagopoulos I, Gorunova L, Bjerkehagen B, Boye K, Heim S.
Oncol Rep. 2014 Jul;32(1):40-4. doi : 10.3892/or.2014.3180
PMID: 24839999 Free

- Gene fusions AHRR-NCOA2, NCOA2-ETV4, ETV4-AHRR, P4HA2-TBCK, and TBCK-P4HA2 resulting from the translocations t(5;8;17)(p15;q13;q21) and t(4;5)(q24;q31) in a soft tissue angiofibroma.
Panagopoulos I, Gorunova L, Viset T, Heim S.
Oncol Rep. 2016 Nov;36(5):2455-2462. doi : 10.3892/or.2016.5096
PMID: 27633981 Free

Paywall references

- Novel MEIS1-NCOA2 Gene Fusions Define a Distinct Primitive Spindle Cell Sarcoma of the Kidney. Argani P, Reuter VE, Kapur P, Brown JE, Sung YS, Zhang L, Williamson R, Francis G, Sommerville S, Swanson D, Dickson BC, Antonescu CR. Am J Surg Pathol. 2018 Aug 31. doi : 10.1097/PAS.0000000000001140 PMID: 30179902

- Fusion of the AHRR and NCOA2 genes through a recurrent translocation t(5;8)(p15;q13) in soft tissue angiofibroma results in upregulation of aryl hydrocarbon receptor target genes. Jin Y, Möller E, Nord KH, Mandahl N, Von Steyern FV, Domanski HA, Mariño-Enríquez A, Magnusson L, Nilsson J, Sciot R, Fletcher CD, Debiec-Rychter M, Mertens F. Genes Chromosomes Cancer. 2012 May;51(5):510-20. doi : 10.1002/gcc.21939
PMID: 22337624